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1

[RSC Drug Discovery] Designing Multi-Target Drugs || Chapter 1. Simple Drugs Do Not Cure Complex Diseases: The Need for Multi-Targeted Drugs

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 240 KB

english, 2012

2

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || High Throughput Screening Approach to Lead Discovery

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 1012 KB

english, 2010

3

The Influence of Target Family and Functional Activity on the Physicochemical Properties of Pre-Clinical Compounds

Morphy, Richard

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 633 KB

english, 2006

4

The Physicochemical Challenges of Designing Multiple Ligands

Morphy, Richard, Rankovic, Zoran

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

5

Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis

Pupo, Gabriele, Ibba, Francesco, Ascough, David M. H., Vicini, Anna Chiara, Ricci, Paolo, Christensen, Kirsten E., Pfeifer, Lukas, Morphy, John Richard, Brown, John M., Paton, Robert S., Gouverneur, V

Journal:

Year:

2018

Language:

english

File:

PDF, 861 KB

english, 2018

6

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Role of Natural Products in Drug Discovery

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 2.69 MB

english, 2010

7

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || In Silico Screening

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 904 KB

english, 2010

8

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || De novo Drug Design

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

9

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Design of Multitarget Ligands

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 470 KB

english, 2010

10

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Fragment-Based Lead Discovery

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

11

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Frontmatter

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 145 KB

english, 2010

12

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Role of Chemistry in Lead Discovery

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 780 KB

english, 2010

13

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Early Screening for ADMET Properties

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 372 KB

english, 2010

14

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || Lead Discovery: The Process

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010

15

Lead Generation Approaches in Drug Discovery (Rankovic/Lead Generation) || INDEX

Rankovic, Zoran, Morphy, Richard

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

16

An in vivo model for screening peptidomimetic inhibitors of gelatinase A

Surinder K. Chander, Pari Antoniw, Nigel R. A. Beeley, Byron Boyce, Thomas Crabbe, Andrew J. P. Docherty, Joanna Leonard, Barbara Mason, Kenneth Millar, Andrew T. Millican, Richard Morphy, Andrew Moun

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 610 KB

english, 1995

17

Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters

David R. Barn, J. Richard Morphy, David C. Rees

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 214 KB

english, 1996

18

A novel linker strategy for solid-phase synthesis

J.Richard Morphy, Zoran Rankovic, David C. Rees

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 185 KB

english, 1996

19

Design, synthesis, and structure–activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists

Elizabeth M. Moir, Kazuya Yoshiizumi, Jim Cairns, Phillip Cowley, Morag Ferguson, Fiona Jeremiah, Takao Kiyoi, Richard Morphy, Jason Tierney, Grant Wishart, Mark York, James Baker, Jean E. Cottney, An

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 311 KB

english, 2010

20

The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain

Derek Angus, Matilda Bingham, Dawn Buchanan, Neil Dunbar, Linsday Gibson, Richard Goodwin, Anders Haunsø, Andrea Houghton, Margaret Huggett, Richard Morphy, Susan Napier, Olaf Nimz, Joanna Passmore, G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 638 KB

english, 2011

21

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Peter Ray, Jane Wright, Julia Adam, Sylviane Boucharens, Darcey Black, Angus R. Brown, Ola Epemolu, Dan Fletcher, Margaret Huggett, Phil Jones, Steven Laats, Amanda Lyons, Jos de Man, Richard Morphy,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.14 MB

english, 2011

22

Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists

James Baker, Matilda Bingham, Ruth Blackburn-Munro, Jiaqiang Cai, Mark Craighead, Robert Gilfillan, Kate Goan, David Jaap, Rachel Milne, J. Richard Morphy, Susan Napier, Jeremy Presland, Gayle Spinks,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 498 KB

english, 2011

23

Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines

J Richard Morphy, Zoran Rankovic, Mark York

Journal:

Year:

2003

Language:

english

File:

PDF, 391 KB

english, 2003

24

Fluorocarbon accelerated supported transformations (FAST) on REM resin

J.Richard Morphy, Zoran Rankovic, Mark York

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 77 KB

english, 2001

25

Low dilution procedures in solid-phase organic synthesis: Diels–Alder and Heck reactions

J.Richard Morphy, Zoran Rankovic, Mark York

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

26

One-pot Hofmann elimination–transesterification/amidation reactions on REM resin using perfluorous solvents

J.Richard Morphy, Zoran Rankovic, Mark York

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 429 KB

english, 2002

27

Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis

Friedrich E.K. Kroll, Richard Morphy, David Rees, David Gani

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 263 KB

english, 1997

28

Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives

J.Richard Morphy, Nigel R.A. Beeley, Byron A. Boyce, Joanna Leonard, Barbara Mason, Andrew Millican, Kenneth Millar, James P. O'Connell, John Porter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 348 KB

english, 1994

29

Potent and selective inhibitors of gelatinase-a 1. hydroxamic acid derivatives

John R. Porter, Nigel R.A. Beeley, Byron A. Boyce, Barbara Mason, Andrew Millican, Kenneth Millar, Joanna Leonard, J.Richard Morphy, James P. O'Connell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 341 KB

english, 1994

30

Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor

Zili An, Xiaoen Wang, Neville Willmott, Surinder K. Chander, Simon Tickle, Andrew J. P. Docherty, Andrew Mountain, Andrew T. Millican, Richard Morphy, John R. Porter, R. Ola Epemolu, Tetsuro Kubota, A

Journal:

Clinical and Experimental Metastasis

Year:

1997

Language:

english

File:

PDF, 953 KB

english, 1997

31

Design and Synthesis of a Maximally Diverse and Druglike Screening Library Using REM Resin Methodology

Barn, D., Caulfield, W., Cowley, P., Dickins, R., Bakker, W. Iwema, McGuire, R., Morphy, J. Richard, Rankovic, Z., Thorn, M.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 389 KB

english, 2001

32

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 810 || Chapter 2. Clinical Need and Rationale for Multi-Target Drugs in Psychiatry

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 430 KB

english, 2012

33

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 810 || Chapter 4. Chemoinformatic Approaches to Target Identification

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 558 KB

english, 2012

34

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 5b || Chapter 8. Historical Strategies for Lead Generation

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 772 KB

english, 2012

35

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 104 || Chapter 3. Drug Molecules and Biology: Network and Systems Aspects

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 471 KB

english, 2012

36

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 810 || Chapter 5. Designing Multi-Target Drugs: In Vitro Panel Screening – Biological Fingerprinting

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

37

Circulation: Cardiovascular Interventions Editors' Picks: Most Important Articles Published in 2011

Morphy, J. Richard, Harris, C John

Journal:

Year:

2012

Language:

english

File:

PDF, 336 KB

english, 2012

38

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 5b || Chapter 9. In Silico Lead Generation Approaches in Multi-Target Drug Discovery

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 680 KB

english, 2012

39

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 14. Discovery of HDAC-Inhibiting Multi-Target Inhibitors

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

40

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 5b || Chapter 7. Target/s Identification Approaches – Experimental Biological Approaches

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 675 KB

english, 2012

41

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 810 || Chapter 10. The Challenges of Multi-Target Lead Optimization

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 478 KB

english, 2012

42

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 810 || Chapter 11. Combination Agents Versus Multi-Targeted Agents – Pros and Cons

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 333 KB

english, 2012

43

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Epilogue

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 155 KB

english, 2012

44

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 15. Targeting Protein–Protein Interactions: Dual Inhibitors of Bcl-2 and Bcl-xL

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

45

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 578 || Chapter 12. The Discovery of Lapatinib

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

46

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 13. Identification and Optimization of Dual PI3K/mTOR Inhibitors

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 671 KB

english, 2012

47

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 19. Designing Drugs with Dual Activity: Novel Dual Angiotensin II and Endothelin Receptor Antagonists

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

48

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 17. The Rational Design of Triple Reuptake Inhibitors for the Treatment of Depression

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 1.71 MB

english, 2012

49

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Subject Index

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 168 KB

english, 2012

50

[RSC Drug Discovery] Designing Multi-Target Drugs Volume 654 || Chapter 20. Ethyl Urea Inhibitors of the Bacterial Type II Topoisomerases DNA Gyrase (GyrB) and Topoisomerase IV (ParE)

Morphy, J. Richard, Harris, C John

Year:

2012

Language:

english

File:

PDF, 853 KB

english, 2012